Metrohm together with USP have started updating numerous wet chemistry methods for pharmaceutical analysis. This newsletter presents some recently modernized methods including an optimized titration method and a new IC method for zinc oxide assay. 

Optimised USP titration method
The optimized USP titration method replaces the visual endpoint detection by automatic potentiometric determination. Users benefit from safer liquid handling and more accurate results. Here are some applications. 

• Determination of assay of Vitamin C according to USP <580> 
• Determination of iodometric assay according to USP<425>
• Surface glass test according to USP<660>

New IC Method recommended
USP has updated the General Chapter <591> «Zinc Determination» monograph to include ion chromatography as the recommended method for measuring zinc oxide assay.
The new IC method is approved by the FDA and benefits users with more ease of use and better data reproducibility.