Polycythemia vera, essential thrombocythemia and primary myelofibrosis, the three major forms of MPN, are most often associated with Janus kinase 2 (JAK2) mutations. However, a large subset of MPN are JAK2 V617F-negative.

Two large scale studies on MPN showed that many of the JAK2 V617F-negative MPNs were positive for both somatic Type I and Type 2 mutations in calreticulin (CALR).

How can you reliably detect somatic mutations in exon 9 of the CALR gene? Find out now!