CALR: the new biomarker for myeloproliferative neoplasm (MPN) research

CALR: the new biomarker for myeloproliferative neoplasm (MPN) research

Anatomy - Pathology

March 21, 2017

Polycythemia vera, essential thrombocythemia and primary myelofibrosis, the three major forms of MPN, are most often associated with Janus kinase 2 (JAK2) mutations. However, a large subset of MPN are JAK2 V617F-negative.

Two large scale studies on MPN showed that many of the JAK2 V617F-negative MPNs were positive for both somatic Type I and Type 2 mutations in calreticulin (CALR).

How can you reliably detect somatic mutations in exon 9 of the CALR gene? Find out now!

 

 

 

Thermometric titration-can you feel the heat?

Thermometric titration-can you feel the heat?

Anatomy - Pathology

Thermometric titration is fast, simple to use, rugged, versatile and unique.
In thermometric titration, the temperature change during a chemical reaction is used for the endpoint detection. This temperature change takes place only while the titrant reacts with the analyte. This makes endpoint detection very easy!
Consequently, the thermometric titrator is the ideal solution for difficult samples with complex matrices that cannot be titrated potentiometrically.

 

 

June 01, 2014 More +
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