New hope for the development of Alzheimer's disease therapeutics from Qiagen!

New hope for the development of Alzheimer's disease therapeutics from Qiagen!

Molecular Diagnostics

August 30, 2018

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by two types of lesions in the brain: extracellular senile plaques consisting of APP-derived amyloid ß (Aß) peptide and intracellular neurofibrillary tangles build out of hyperphosphorylated microtubule-associated tau protein. 

One process that could contribute to memory loss in AD due to synapse loss and neuronal cell death is the intracellular caspase cleavage of the amyloid precursor protein (APP), producing APP delta C31 and C31.

This review focuses on a high-throughput screening of small molecules that inhibit the APP-C31 generating cleavage pathway as part of AD drug discovery.

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Directly conjugated primary antibodies for imaging and flow cytometry from Abcam!

Directly conjugated primary antibodies for imaging and flow cytometry from Abcam!

Molecular Diagnostics

Design your multicolor experiments easily with directly conjugated primaries from Abcam for all your favorite neuroscience proteins. Not only your staining will be extra fast, but you will avoid the stress of finding compatible antibodies!

Click here to ​discover the full selection of conjugated primary antibodies against neuronal and glial markers, including Alexa Fluor® dyes and fluorescent proteins.

 

August 01, 2019 More +
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