New ipsogen BCR-ABL1 Mbcr RGQ RT-PCR Kit (CE)

New ipsogen BCR-ABL1 Mbcr RGQ RT-PCR Kit (CE)

Molecular Diagnostics

June 17, 2015

Qiagen is happy to announce the launch of the next CE-IVD assay for our PHC blood cancer portfolio: The ipsogen BCR-ABL1 Mbcr RGQ RT-PCR kit.

The ipsogen BCR-ABL1 Mbcr RGQ RT-PCR kit is an in-vitro diagnostic test to quantify the BCR-ABL1 fusion gene b3a2 (e14a2) and b2a2 (e13a2) transcripts in total RNA extracted from whole blood. It uses the RNeasy kit for extraction and runs on the Rotor-Gene Q MDx.

This is the first commercial kit to provide deep molecular response status for BCR-ABL1 transcripts present in patients diagnosed with chronic phase Philadelphia chromosome positive (Ph+) p210 chronic myeloid leukemia (CML). To achieve deep molecular response, quantification down to a limit of detection (LOD) lower than 0.0030% is required. The new ipsogen BCR-ABL1 Mbcr RGQ RT-PCR kit is hence the most sensitive commercial leukemia test on the market.
Such low levels of sensitivity are in-line with the latest oncohematology expert recommendations for the management of CML. If a patient under latest generation tyrosine kinase inhibitor therapy (e.g nilotinib) achieves deep molecular response, the levels of BCR-ABL1 in the blood are 4.5 logs, or 10,500 times, lower than they were before the treatment started. These patients are then considered to be in remission, and after a period of time may have the option of living free of drug therapy. This is another good example how QIAGEN sample-to-insight solutions can impact the treatment of life-threatening diseases such as leukemia and help to provide best therapy options for patients.

Mycotoxins in Edible Oils

Mycotoxins in Edible Oils

Molecular Diagnostics

R-Biopharm has recently received a number of enquiries from customers asking about testing edible oils for mycotoxins.

Currently maximum levels are set for various mycotoxins including aflatoxins, ochratoxin A, patulin and the Fusarium toxins (deoxynivalenol, zearalenone and fumonisins) /Commission Regulation (EC) No.1881/2006.

April 01, 2013 More +
Exosomes – small vesicles, big players

Exosomes – small vesicles, big players

Molecular Diagnostics

Functional study of exosomes and exoRNAs starts with isolation. Are you still performing time-consuming ultracentrifugation to isolate the contents of exosomes and other extracellular vesicles?

January 11, 2017 More +
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